Furthermore, as observed in vitro for PLP139-151-specific encephalitogenic T cell lines, cells isolated from PTTH-treated EAE mice produce significantly lower amounts of pro-inflammatory cytokines crucial for EAE and MS development, such as IL-6, IL-17, IFN-γ and GM-CSF [4], upon ex-vivo re-stimulation, compared to LN cells from control mice (Fig. 4d). Here, CSF2 is linked to myeloid sarcoma.