PANK1 and early-onset autosomal dominant Alzheimer disease: Interestingly, previous studies found that administration of PTTH had beneficial effects in several animal models of neuroinflammation and neurodegeneration, such as cerebral malaria, pantothenate kinase-associate neurodegeneration, Parkinson’s disease and Alzheimer’s disease [6, 11, 15, 16, 38, 43, 57].