For instance, we and others have shown that the Insulin-like Growth Factor 1 (IGF1), and the chemokines CCL5 and interleukin-8 (IL-8), which have a documented role in BC progression, are molecules produced by AT and represent key signals in the communication between adipose and BC cells (Li et al. 2021; Ambrosio et al. 2017; D'Esposito et al. 2012, 2016; Ji et al. 2021; Xu et al. 2021). This evidence concerns the gene CXCL8 and breast cancer.