Additionally, Vdovikova et al. showed that a small number of genes (e.g., RND3, TACSTD2, SOCS2, and ARL5B) are differentially regulated by membrane vesicles of pathogenic and non-pathogenic bacteria in the gut(Vdovikova et al. 2018), and SOCS2 has been found to be possibly associated with the tumorigenic potential of CRC (Kim et al. 2018), suggesting that some bacteria in the gut may inhibit CRC development. This evidence concerns the gene RND3 and colorectal carcinoma.