Thus, no phenotype analyses were done for ANKRD26. MECOM and SRP72 heterozygotes were more common than the hematopoietic transcription factor group, but less common than DDX41. While HM has been reported (albeit rarely) in patients with MECOM germline P/LP variants, in these cohorts only one individual in UKBB had an HM (an AML) and none in DiscovEHR. This evidence concerns the gene DDX41 and acute myeloid leukemia.