In the comparison between patients with and without the aggravation of VS, those with VS aggravation tended to have a longer duration of RA (p = 0.010)—particularly ≥ 5 years (p < 0.001), higher level of CRP at baseline (p = 0.052)—especially ≥ 3.8 mg/dL (p = 0.009), higher frequency of previous peripheral joint surgery (p < 0.001), corticosteroid administration (p = 0.008), and mutilating changes in the hands (p < 0.001) at baseline. The gene discussed is CRP; the disease is rheumatoid arthritis.