Interestingly, data from the DepMap database for CDKN2A copy numbers and EED dependency in the lung, endometrial, and ovarian tumor cells indicated that the CDKN2A deletion cells (copy number <1) are generally not responsive to EED perturbations (Supplementary Fig. S10A), suggesting that CDKN2A copy number loss may serve as a reference biomarker for the resistant cells. Here, CDKN2A is linked to ovarian neoplasm.