MKI67 and neoplasm: The levels of a proliferation marker (Ki67) and the senescence marker, p16, were also investigated in tumor samples by immunohistochemical (IHC) staining (Fig. 5G, I), and these experiments demonstrated that BR0063 significantly (P < 0.0001, Fig. 5H, I, K, L) reduced cell proliferation and induced senescence in both xenograft models that were treated with 80 mpk BR0063, findings that were in agreement with the results obtained in vitro.