Our immunofluorescence staining revealed that endogenous USP3 and SMARCA5 were mainly colocalized in the nuclear in both two PCa cells (Fig. 3D) (Supplementary Fig. S3D) and then we found that endogenous USP3 and SMARCA5 coprecipitated in PC3 cells (Fig. 3E). Here, SMARCA5 is linked to posterior cortical atrophy.