Our immunofluorescence staining revealed that endogenous USP3 and SMARCA5 were mainly colocalized in the nuclear in both two PCa cells (Fig. 3D) (Supplementary Fig. S3D) and then we found that endogenous USP3 and SMARCA5 coprecipitated in PC3 cells (Fig. 3E). This evidence concerns the gene USP3 and posterior cortical atrophy.