Among the TOP4 interacted proteins (TTN, POTEE, EBNA1BP2 and SMARCA5) (Supplementary Tables S2), only SMARCA5, a chromatin-remodeling enzyme, was overexpression in PCa tissues (Supplementary Fig. S3C) and required for DNA-templated events including transcription, DNA replication, and DNA repair [18]. The gene discussed is TTN; the disease is posterior cortical atrophy.