As shown in Fig. 7G, ZNF652 overexpression led to higher levels of apoptotic proteins caspase 3 and cleaved caspase 3 induced by palbociclib (a CDK4/6 inhibitor) in LC cells, indicating that ZNF652 overexpression enhanced LC apoptosis induced by palbociclib. The gene discussed is CASP3; the disease is laryngotracheoesophageal cleft.