Moreover, recent studies have demonstrated that OTUB1 acts as a major regulator of SLC7A11 stability in several cancer cell lines, including lung cancer (H1299), neuroblastoma (SK-N-BE(2)C), osteosarcoma (U2OS), and bladder cancer (T24 and UM-UC-3) cells [26]. This evidence concerns the gene OTUB1 and neuroblastoma.