IKZF1 and Miyoshi myopathy: In addition, their degradation has been found to enhance IL-2 expression and the proliferation of NK and T cells, thereby offering an effective mechanism for modulating immune functions.255–259 IKZF1 and IKZF3 degraders, such as thalidomide and lenalidomide, have been recognized for their therapeutic efficacy in MM.260 The structural elucidation of the DDB1-CRBN-lenalidomide complex68 has propelled forward our molecular understanding and the development of effective TPDs.