For pan-cancer applications, TL13-12 (ALK degrader) addresses kinase-related malignancies; ARV-825 and AUTAC3 (BRD4 degraders) focus on epigenetic regulation; dp53m-RA degrades p53, related to apoptosis; NVP-DKY709 targets IKZF2; CC-90009 is a GSPT1 degrader; 21a degrades PD-L1. The gene discussed is TP53; the disease is cancer.