IKZF3 and non-Hodgkin lymphoma: It effectively induces rapid and sustained degradation of IKZF1 and IKZF3, and apoptosis in malignant cells.331 In addition, synergistic effects have been observed when CC-99282 is combined with anti-CD20 monoclonal antibodies.331 In a Phase I study, CC-99282’s safety and efficacy were evaluated in patients with R/R NHL.