Considering this effect of thalidomide analogs, Yang et al. introduced a substituted phenyl ring to thalidomide to promote the selective degradation of HDAC6.285 Besides, VHL-based PROTACs also displayed selective degradation at nanomolar half-maximal degradation concentration (DC50) without significant cytotoxicity.285 Hansen’s group provided an alternative synthetic way.286 They employed innovative solid-phase synthesis approach to create both hydroxamic acid-based and non-hydroxamic acid-based PROTACs with potent degradation but suboptimal cell cytotoxicity in MM.287,288. Here, HDAC6 is linked to Miyoshi myopathy.