PNPLA3 and fatty liver disease: PNPLA3, also known as adiponutrin, plays a key role in fat metabolism in the liver and adipose tissue by hydrolyzing triglycerides and retinyl esters.550 Genetic variations in PNPLA3 significantly contribute to the development of fatty liver disease (FLD) due to its involvement in hepatic lipid metabolism.551,552 BasuRay et al. observed that the accumulation of PNPLA3 on lipid droplets leads to steatosis.