They also developed a ROS-triggered PROTAC, enhancing its degradation activity and cell selectivity in the presence of NQO1 and β-Lap.686 While the approach by harnessing the specific biology of the tumor environment to provide better selectivity is promising, it is important to note that further investigations are needed to extend the utility of the approach for therapy development due to the heterogeneity of tumors. This evidence concerns the gene NQO1 and neoplasm.