Zhu et al. developed another CMA-based degrader (TAT-CDK5-CTM peptide), which can penetrate cell membranes and showed in a mouse stroke model that it disrupts the CDK5-NR2B interaction, causing CDK5 degradation linked to stroke.538 Significant advancements have been made in elucidating the role of CMA in neurodegenerative disorders. This evidence concerns the gene HSF4 and Stroke.