HTT and Huntington disease: HD is a hereditary neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms.534 The pathogenesis of HD is primarily linked to the abnormal expansion of the huntingtin protein (HTT), which leads to protein dysfunction and gradual neuronal damage.535 Current treatments for HD focus mainly on managing symptoms with antipsychotic and antidepressant medications, which alleviate psychiatric and motor symptoms but do not halt disease progression or slow the degenerative process.