In addition, CC-92480 is also effective in overcoming IMiD resistance in T-cell lymphomas by degrading both IKZF1 and ZFP91, which are crucial for T cell lymphomas survival.273 These studies validate the enhancement of CC-92480 role in MM and potentially other hematologic malignancies treatment. This evidence concerns the gene ZFP91 and T-cell non-Hodgkin lymphoma.