PDE6D and cancer: PDEδ is a prenyl-binding protein that assists in the transport and localization of the Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) protein in cells.386 Targeting PDEδ in pancreatic cancer could disrupt this transport mechanism, and inhibit the oncogenic activity of KRAS, which is frequently mutated in this cancer type.387 Sheng’s group reported a series of ATTECs with GW5074 as the LC3 binder to degrade PDEδ, and the most promising compound 12c caused the degradation of PDEδ via lysosome-mediated autophagy without interfering with PDEδ mRNA synthesis.248