The TRIM24 degrader, dTRIM24, has shown potent anti-tumor effects in preclinical trials for glioblastoma and AML.572,573 In addition, TRIM24 plays a critical role in immune regulation by inhibiting the acetylation of STAT6, which promotes the polarization of macrophages towards the M2 phenotype. The gene discussed is TRIM24; the disease is acute myeloid leukemia.