Zhu et al. developed another CMA-based degrader (TAT-CDK5-CTM peptide), which can penetrate cell membranes and showed in a mouse stroke model that it disrupts the CDK5-NR2B interaction, causing CDK5 degradation linked to stroke.538 Significant advancements have been made in elucidating the role of CMA in neurodegenerative disorders. This evidence concerns the gene GRIN2B and stroke disorder.