PTPN1 and nervous system disorder: Moreover, it reduced the area under the curve of blood glucose from 0 to 2 h to 29% in KM mice, showing promise for long-term antidiabetic therapy.583 Besides, PTP1B inhibitors have shown promising effects in other diseases such as cancers,584 immunity,585 and neurological disorders.586 PTP1B degraders are expected to improve treatment for these diseases.