Given the shift in diagnostic pathology toward the use of integrated histopathologic and genomic approaches, the incorporation of additional molecular strata in the classification of NF1-associated peripheral nerve sheath tumors should be formalized to aid in accurate diagnosis and early identification of malignant transformation to enable appropriate intervention for affected patients.45 Here, we provide a consensus-integrated diagnostic approach for ANNUBP and MPNST (Table 2; Figure 1A). The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.