Western blot results demonstrated that the total Ac‐Lys, H2AK5ac, H3K9ac, H3K14ac, H4K8ac, H4K12ac, and H4K16ac proteins were significantly reduced in AD mice and SH‐5Y5Y cell models, and these changes were significantly alleviated after overexpression of TIP60 (Figure S1A,B). This evidence concerns the gene KAT5 and Alzheimer disease.