SCNN1G and Hypernatremia: Although immunostaining and immunoblots show greater γENaC levels in both male and female Myh9&10 TAL-cKO mice at 13 weeks of age, transcript analysis indicates that higher Scnn1g gene expression occurs earlier in female Myh9&10 TAL-cKO mice (at 9 weeks) compared to male Myh9&10 TAL-cKO mice (at 16 weeks), potentially contributing to the sex-specific differences seen in the onset of hypernatremia.