Female Myh9&10 TAL-cKO mice develop severe hypernatremia at 12 weeks, the time at which they become moribund, with an average serum sodium level of 157.3 ± 0.99 mmol (mean ± SEM) compared to controls at 150.5 ± 0.6 mmol (mean ± SEM) (Table 1). The gene discussed is MYH9; the disease is Hypernatremia.