They demonstrating that antagonism of 5-HT6R blocked scopolamine-induced stretching behavior in rats [106], indicating modulation of cholinergic neurotransmission by 5-HT6R. Furthermore, 5-HT6R antagonism not only enhances cognitive function in normal rats but also ameliorates scopolamine-induced cognitive deficits by enhancing cholinergic neurotransmission [107, 108]. Here, HTR6 is linked to Cognitive impairment.