RAB10 and Parkinson disease: Our study further supports the critical role of Rab10 in cells, pointing out that the reduced phosphorylation of Rab10 triggered by the R1627P mutation may interfere with the communication and fusion between the Golgi apparatus and lysosomes, resulting in the accumulation and aggregation of vesicles, impacting cellular metabolism and clearance functions, which may be early contributors to the PD pathogenesis.