Interestingly, adequate Drp1 modulation is considered essential for the mitochondrial function in neurons, and disequilibrium in mitochondrial dynamics, towards fission, was identified as an important mechanism responsible for the vulnerability of dopaminergic neurons in PD, and, consistent with this, inhibition of excessive mitochondrial fission, using a Drp1 blocker, led to neuroprotection [62]. The gene discussed is DNM1L; the disease is Parkinson disease.