PLEKHO1 and leukemia: Cdkn2a-WT MYB::PLEKHO1 leukemias showed intact expression of p16INK4A and p19ARF, while Cdkn2a-KO leukemias did not, confirming that MYB::PLEKHO1 is indeed able to induce leukemia independently of Cdkn2a loss (Supplemental Figure 4C).