Interestingly, we found that, in the case of MYB-TR (which models the MYB::ZFAT fusion recurrent in BPDCN) (2), overriding the G1/S checkpoint by Cdkn2a KO was also required for leukemic transformation. The gene discussed is CDKN2A; the disease is CD4+/CD56+ hematodermic neoplasm.