Comparing Cdkn2a-WT MYB-WT cells (which do not induce leukemia in vivo) with Cdkn2a-WT MYB::PLEKHO1 cells (which do induce leukemia), genes that showed both increased expression in MYB::PLEKHO1 cells and binding of MYB at the promoter were enriched for G2/M cell cycle regulators such as Cdc20, Ccp110, and Kif20a (Supplemental Figure 6, C–E). This evidence concerns the gene CDC20 and leukemia.