The Pde6anmf363/nmf363 mouse (hereafter referred to as Pde6a mice), which carries a missense mutation (c.2009A>G, p.D670G) in the Pde6a gene and exhibits moderate photoreceptor degeneration, has been used to model Pde6a-related RP (8, 29). This evidence concerns the gene PDE6A and retinitis pigmentosa 1.