TNF and type 2 diabetes mellitus: Earlier study indeed have shown that hyperglycemic conditions in T2D induced constitutive NETosis and further neutrophils failed to form NETs in response to LPS.[48] Moreover, it was observed that in T2D, neutrophils on treatment with IL‐6, LPS and TNF‐α did not form any extended NETs.[50, 51] Therefore, NETosis may not be induced by LPS or oral microbial dysbiosis in this model, which can also indirectly affect neutrophil functioning.