SLC2A1 and Hyperglycemia: Prior study demonstrated the metabolic requirement of NETs formation where, chromatin condensation was glucose‐independent and however, glucose was required for chromatin release during NETosis.[61] When treated with hexokinase inhibitor, 2‐deoxyglucose (2‐DG), neutrophils reduced NETs formation in response to glucose.[48] Inhibition of GLUT1 protects db/db mice from NETs‐mediated inflammatory bone loss, implying that GLUT1 contributes to periodontitis in individuals with hyperglycemia and/or compromised metabolic function, at least partly, through NETosis.