Higher levels of glucose and advanced glycation end products (AGEs) in diabetes can induce neutrophil activation and subsequently escalated oxidative stress via RAGE‐ERK1/2 pathways.[1] Elevation of ROS may be one of the reasons for the constitutive production of NETs in hyperglycemic conditions.[48] Persistent hyperglycemia is often accompanied by increased production of free radicals or impaired antioxidant defenses. Here, MAPK3 is linked to Hyperglycemia.