Consistent with our expectations, SPOP revealed a positive correlation with key steps of the cancer‐immunity cycle, such as the release of cancer cell antigens (Step 1), cancer antigen presentation (Step 2), trafficking of immune cells to tumors (Step 4) (i.e., CD4 T cell, CD8 T cell, macrophage, and monocyte recruitments) and infiltration of immune cells into tumors (Step 5) in COAD, READ, or LUAD (Figure 10H–J). Here, CD8A is linked to colon adenocarcinoma.