IVL and neoplasm: Cytokeratin 17 (CK17), a TIC marker in the cervix, was induced by PIWIL2 overexpression but abolished by PDK1 silencing; expressions of the epithelial differentiation markers involucrin and loricrin were conversely altered by PDK1 modulation (Figure 3M,N), which may contribute to tumor suppression via targeting PDK1.