PDK1 and neoplasm: It promotes glycolytic metabolism via negatively regulating pyruvate dehydrogenase (PDH) and thereby inhibiting pyruvate entry into the tricarboxylic acid (TCA) cycle.[11, 13] PDK1 has been verified to play a key role in enhancing cellular reprogramming and tumor progression.[11, 14] Therefore, we can speculate that PDK1 participates in determining the outcome of SIL via controlling TIC maintenance.