Our previous study confirmed that the reactivation of PIWIL2 expression by HR‐HPV oncoproteins initiated cellular reprogramming, subsequently leading to TIC formation and cervical tumorigenesis.[6b] In this study, our data showed that PIWIL2 overexpression in HCBC cells and the normal keratinocyte cell line HaCaT via lentiviral transduction significantly upregulated PDK1 expression (Figure 2B,C). This evidence concerns the gene PIWIL2 and cervicitis.