LIN28A/B and let‐7 regulate PI3K‐AKT‐mTOR signaling to switch on metabolic reprogramming in cancer cells.[14, 17, 24] We also verified PI3K‐AKT‐mTOR pathway activation in HaCaT cells and HeLa cells with PIWIL2‐mediated reprogramming. The gene discussed is AKT1; the disease is cancer.