Cell proliferation, the process driving cancer cells’ multiplication and tumor formation, is a critical factor in cancer progression, particularly BC.[24, 25] Uncontrolled cell proliferation fuels the growth of cancerous tissues and metastasis, emphasizing the importance of understanding and targeting proliferation pathways for therapeutic interventions.[26] Our study observed an overexpression of TBL2 in BC, correlating with an elevated risk of tumor recurrence and reduced patient survival rates. Here, TBL2 is linked to breast cancer.