Transducin beta‐like 2 (TBL2), a member of the WD40 repeat protein family, is involved in regulating intracellular signaling pathways, including TGF, PERK, and PI3K‐AKT signaling pathways.[18, 19, 20] Emerging research suggests that TBL2, acting as a driver gene, enhances endoplasmic reticulum stress and promotes the proliferation of lung adenocarcinoma cells.[21] Abnormal TBL2 regulation has been linked to various diseases such as Williams‐Beuren syndrome, dyslipidemia, and bladder cancer,[22] while its exploration in BC remains limited. Here, TBL2 is linked to metabolic syndrome.