Activation of CCR2 in macrophages is essential for their polarization toward a pro‐tumor phenotype.[37] CSF‐1 is a major survival factor for TAMs and triggers TAMs polarization by interacting with the CSF1 receptor.[38] Blocking the CCR2 receptor and CSF1 receptor, respectively, could significantly reduce SLITRK4 overexpression‐induced TAMs infiltration and polarization (Figure 4c). Here, CCR2 is linked to neoplasm.