For example, SLITRK4 and SLITRK5 are mainly expressed on progenitor cells, immature human hematopoietic stem cells as well as HUVECs.[25] Our current study demonstrated for the first time that inhibition of SLITRK4 reduced CRC liver metastasis in vitro and in vivo. This evidence concerns the gene SLITRK5 and colorectal carcinoma.