COMP and breast cancer: Emerging evidence shows that COMP has a positive relationship with poor survival in a variety of cancers, including breast cancer, CRC, and hepatocellular carcinoma.[30, 31, 32] COMP governs cytoskeletal remodeling and promotes CRC cell metastasis via interacting with the actin‐binding protein transgelin (TAGLN) in the EMT process.[31] Consistently, COMP overexpression existed in CRC patients and was correlated with poor progression of CRC, and importantly, the expression of COMP and the EMT process were significantly regulated by SLITRK4.