In addition, overexpression of SLITRK4 boosted the transcription of cytokines related to macrophage polarization, such as IL‐8, CCL2, GDF15, and CSF‐1 by activating the PI3K/AKT/NFκB pathway, and enhanced the infiltration of CD206+CD11b+TAMs in CRC liver metastases. This evidence concerns the gene NFKB1 and colorectal carcinoma.