LMAN1 and Thrombocytopenia: To determine whether the thrombocytopenia results from LMAN1 deficiency specifically in the hematopoietic compartment, mice with tissue-specific knockout of Lman1 in hematopoietic and endothelial cells were generated by crossing the Lman1fl allele to the Tie2-Cre transgene (Figure 4A and Table 1).