We observed that intellectual disability (ID), also known as mental retardation, was an enriched term for co-regulated proteins for several of the m6A and m5C methylation effector proteins, namely, METTL16, WTAP, RBM15, YTHDC1, YTHDF1, YTHDF2, ALKBH5, NSUN1, NSUN2, NSUN4, NSUN5 and YBX1. This evidence concerns the gene YBX1 and Intellectual disability.