In a PAN02 bilateral subcutaneous tumor model (Fig. 5), although OBP-702 treatment significantly increased mature DCs in draining lymph nodes compared with OBP-301, Ad-p53 treatment also increased mature DCs to a similar level as OBP-702, proving the importance of p53 in DC maturation by OBP-702. This evidence concerns the gene TP53 and neoplasm.