BMP4 and obesity due to melanocortin 4 receptor deficiency: Among the various BMP ligands, BMP2 and BMP4 have been described to be expressed in the human pancreas,[25, 26, 27] and upregulated in the vasculature of animal models for T1DM and T2DM.[28, 29] Furthermore, BMP2 and BMP4 are linked to beta cell dysfunction, obesity, and T2DM.[30, 31, 32] BMP2 and BMP4 diverge from a common ancestral gene and their protein sequences are highly similar.[33]