INS and fatty liver disease: Moreover, spermidine was observed to normalize the number of Kupffer cells in the livers of mice with NASH; however, these beneficial effects did not translate into improvements in liver steatosis or fibrosis severity.[73] In a separate study, Ni et al.[74] reported that spermidine supplementation significantly reduced insulin resistance, steatosis, steatohepatitis, and fibrosis in a murine models of MASH induced by a Western diet.