Since Sirt1 has been reported to relieve intracellular oxidative stress and improve cellular lipid metabolism disorders,[13, 14, 15] and our previous studies demonstrated the renoprotective role of Sirt1 in CaOx nephrocalcinosis,[19] we hypothesized that Sirt1 is a novel target for inhibiting CaOx‐induced ferroptosis and kidney injury. Here, SIRT1 is linked to Disorder of lipid metabolism.