CD8+CD137+ T cells or CD8+IFN‐γ+ T cells within tumor tissues denote ETASTs, which are more indicative of immune activation features compared to CD8+ T cells alone.[32] These studies revealed that TTNP significantly increased ETAST levels in the TME (Figure 3f,g; Figures S5 and S6, Supporting Information), and combining it with αPD‐1 further increased ETAST levels in the tumor. Here, TNFRSF9 is linked to neoplasm.