Consistently, cccDNA‐specific chromatin immunoprecipitation (ChIP) assay in HBV‐infected HLCZ01 cells,[24] a human hepatoma cell line that supports the entire lifecycle of HBV, showed that ABCF1 significantly accumulated with cccDNA (Figure 1C), but failed to bind host genomic DNA, including GAPDH, RPL30, and MYOD1 (Figure S1A, Supporting Information). The gene discussed is ABCF1; the disease is hepatocellular carcinoma.