Patients with low CT‐TME scores were enriched with ARID1A and PIK3CA mutations, where PIK3CA mutation is associated with a good prognosis in STAD patients.[42]ARID1A mutation is a biomarker associated with immune response in STAD (Figure 7C,D).[43] In addition to this, we also discovered that most of the high CT‐TME scores were EBV‐negative and most of the STAD patients with low CT‐TME scores were Epstein‐Barr Virus (EBV) subtype (Figure 7E,F). Here, PIK3CA is linked to gastric adenocarcinoma.