The synthesis and metabolic network of LysoPC are extremely complex, and the exact mechanism for its reduction is not clear at this time, but it is hypothesized to be related to the changes in several enzyme activities found in severe infections, such as secretory phospholipase A2 (SPLA2), cholesterol acyltransferase (LCAT), and lysophosphatidylcholine acyltransferase (LPCAT) (Ahn et al., 2017). The gene discussed is PLA2G2D; the disease is infection.