RelA/p65 Ser536 phosphorylation suppresses HCC progression and metastasis by inhibiting NF-κB p65 nuclear translocation; decreasing NF-κB p65 binding to BCL2, SNAIL, and MMP9 promoters; and downregulating BCL2, SNAIL, and MMP9 expression (Figure 9). The gene discussed is NFKB1; the disease is hepatocellular carcinoma.