HIF1A and metabolic dysfunction-associated steatohepatitis: Additionally, research has demonstrated that digoxin inhibits inflammasome activity maintained by the HIF-1α pathway in a nonalcoholic steatohepatitis (NASH) mouse model, thereby validating its role as an inhibitor of HIF-1α activation (Ouyang et al., 2018; Zhang et al., 2008; Zhao et al., 2019).