p120 can facilitate the transformed growth of human breast cancer cells through Rac1 activation and Rac1-mediated MAPK signaling, and modulate the invasion and migration of GnRH-induced human ovarian cancer cells through modulating Rac1 and Cdc42 (Soto et al., 2008; Cheung et al., 2010). The gene discussed is RAC1; the disease is ovarian carcinoma.