TPR and acute lymphoblastic leukemia: Zhang et al. (2023) identified 12 heterogeneous B cell populations in scRNA-seq analysis of Ph-like ALL patients with a novel TPR-PDGFRB fusion gene, revealing a comprehensive profile and dynamic changes in cell composition. Sequencing analysis of 1,507 single cells isolated from BM from four pediatric T-ALL patients by De Bie et al. (2018) and coinvestigators determined clonal heterogeneity in primary T-ALL samples and identified genomic lesions that initiate T-ALL in multipotent progenitor cells.