An animal study on rats also showed similar results, although the exact mechanism has not been elucidated, the study found that rats with high levels of FSH after ovariectomy were more likely to be depressed, and Danshen-Honghua could improve the stress-induced depression syndrome in stressed rats by regulating the level of FSH (Gu et al., 2018b). Here, BRD2 is linked to depressive disorder.