Notably, individuals in the high NHR group in quartile 4 exhibited a significantly elevated risk of developing CVD, with an HR of 1.74 (95 % CI 1.05–2.88), even after adjustment for age, sex, hypertension, diabetes, LDL, fasting glucose, renal function CRP, estimated Glomerular filtration rate, statin use, antihypertensive agents, systolic blood pressure, and the white blood cell count. This evidence concerns the gene CRP and hypertensive disorder.