I3A simultaneously increased the cytotoxic granzyme B production in the recruited CD8+ T cells via the upregulation of essential transcription factors Blimp1 and lfng. Combinatorial treatment including LR along with anti-PD-L1 or anti-CTLA-4 therapy exhibited pronounced cytotoxic T-cell response in the tumor (Bender et al., 2023b) microenvironment and better control than the ICI therapies given individually. Here, CD8A is linked to neoplasm.