SELE and cancer: Vascular E-selectins stimulate mesenchymal to epithelial transition through Wnt signaling and NG2+ cells reinforce dormancy via TGF-beta secretion however, endothelial derived E-selectin stimulates the migration of DTCs to endosteal surface which harbours osteoblasts, MSCs and osteoprogenitors that modulate cancer proliferation via several mechanisms involving mTOR signaling, calcium signaling, epigenomic modification etc., subsequently leading to bone metastasis (Satcher and Zhang, 2022).