The IL family, such as IL-6, IL-4, and IL-10, can polarize TAMs toward the M2 type with the pro-tumor effect and diminished antigen-presenting ability (Biswas and Mantovani, 2010; Locati et al., 2020), which can decrease T-cell infiltration and promote the establishment of an immunosuppressive TME (Gottlieb et al., 2017). Here, IL6 is linked to neoplasm.