In the TB group, 13 metabolic pathways, including fatty acid metabolism, steroid biosynthesis, taurine and hypotaurine metabolism, valine, leucine, and isoleucine degradation, flavonoid biosynthesis, and glycerolipid metabolism, were enriched, while 12 pathways, such as glycine, serine, and apoptosis, PPAR signaling pathway, and pantothenate and CoA biosynthesis, were significantly downregulated. The gene discussed is PPARA; the disease is tuberculosis.