Even after taking age into account, there was a significantly higher probability of STAT3 mutation in RA patients compared to HCs across both mutation types (Either Y640F or D661Y p=1.74x10-6, Y640F alone p=4.57x10-5, D661Y alone p=0.00465) (Figures 3B–D). This evidence concerns the gene STAT3 and rheumatoid arthritis.