CD8A and mantle cell lymphoma: Additionally, the cytotoxic-driven pathology is observed in the skin lesions of patients (5–7), where comparative analyses between mucocutaneous leishmaniasis (MCL) and cutaneous leishmaniasis (CL) show an enrichment of CD8+ T cells with significant pro-inflammatory and cytotoxic activities and tissue destruction in MCL lesions compared to CL lesions (6, 8–10).