The mice injected with CT26 colon carcinoma cell line showed typically two patterns of tumor growth: a small number of mice (2 out of 10 mice) responded well to anti-PD-L1 treatment and rejected the tumors, while the majority of mice showed only a partial response to the treatment, with tumors progressing, although at reduced speed (Figure 1A). This evidence concerns the gene CD274 and colon carcinoma.