ITGAM and neoplasm: al, showed that MDSCs from tumor-bearing mice, synthesize and secrete S100A8/A9, and that in vivo treatment using an anti-carboxylated glycan antibody, which was shown to bind S100A8/A9, reduced the accumulation of Gr1+CD11b+ cells (denoted as MDSCs) in the blood, spleen and lymph nodes.