Evidence suggests that the PI3K/AKT and RAS/RAF pathways are related to cancer formation, so YB1 is inextricably linked with cancer; YB1, through its role as a splicing factor, participates in regulating RNA splicing processes, thereby affecting the ERK signaling pathway; YB1 has been found to be a key factor in the persistence of JAK2 mutant tumors. The gene discussed is AKT1; the disease is cancer.