YB1 can interact with linc00665 and activate the YB1-ANGPT4/ANGPTL3/VEGF axis to induce tumor-related angiogenesis in LUAD (58);YB1 can also bind to the GC boxes in the promoters of Klf4, SM22α, p21, and cyclin D1, promoting VSMC differentiation. The gene discussed is YBX1; the disease is neoplasm.