YB-1 binds to the IRES sequence in the 5′ UTR region of HIF1-α mRNA, activating HIF-1α at the translational level, thereby enhancing the invasion and metastatic capabilities of sarcoma cells, highlighting the importance of the translationally regulated YB-1-HIF1α axis in sarcoma metastasis (37, 76–78). Here, HIF1A is linked to sarcoma.