RBM10 forms a ternary complex with YB1 and PPM1B to inhibit YB1 phosphorylation, or natural products such as lacquer yellow, TAS0612/everolimus inhibit AKT/mTORC1-mediated phosphorylation of YB1 at ser102, thereby inhibiting tumor drug resistance and further development (63, 98–100). This evidence concerns the gene AKT1 and neoplasm.