YBX1 and cancer: In mouse models, YB1 in endothelial cells can upregulate the motility of endothelial cells and the secretion of angiogenic factors in extracellular vesicles (including exosomes), thus playing a crucial role in endothelial cell-induced tumor formation and angiogenesis and YB-1 is transferred to human umbilical vein endothelial cells (HUVECs) via gastric cancer cell-derived exosomes, directly promoting cancer angiogenesis by upregulating key angiogenic factors (57).