Besides the methylated genes common to various cancer types (GSTP1, CDKN2A, RB1, MLH1, APC, PTEN, DAPK1, MSH6, MGMT, RASSF1A, TIMP3, BRCA1, CDH1, VHL, CDKN2B, FHIT, TWIST1, ONECUT2, WIF1, HIC1, PRAC1, SFRP5, RUNX3, SOCS1, etc.)and more specific to BC (ZNF154, HOXA9, POU4F2, EOMES, ACOT11, PCDHGA12, CA3, PTGDR, TBX4, FGFR3, PMF1, PCDH8, PCDH17, GDF15, KISS1, ISL1, ALDH1A3, TBX3, etc.), new candidate genes will be found as further studies are performed, which can be used for screening, diagnostic and prognostic purposes (63–65). The gene discussed is MSH6; the disease is breast cancer.