In contrast, among subjects with hypertension, FOXO3 TG/GG genotype was associated with an apparent protective effect against incident CAD compared to the major allele homozygote TT (HR = 0.83, p = .014, for Japanese-ancestry cohort; HR = 0.66, p = .054, for Okinawan-ancestry cohort; and HR = 0.82, p = .0053, for the Kuakini HHP cohort). This evidence concerns the gene FOXO3 and hypertensive disorder.