FOXO3 and hypertensive disorder: Recently, we found that the longevity genotype of FOXO3 moderated the increased risk of late-life hypertension in Alzheimer’s disease (7), attenuated the deleterious impact of chronic hypertension on the long-term risk of spontaneous intracerebral hemorrhage, possibly by providing cerebrovascular resilience and protection against the adverse effects of chronic hypertension (8), and attenuated the impact of hypertension on the risk of cerebral microinfarcts identified in autopsies of deceased individuals in our cohort (9).