CRK and chronic myelogenous leukemia, BCR-ABL1 positive: The human ortholog of Abl tyrosine kinase (ABL1) is associated with chronic myeloid leukemia and the human ortholog of Crk (CRK) is a proto-oncogene [32], which could plausibly be relevant to potential carcinogenic effects of 4-methylimidazole [4, 8, 9].