CD4 and glioblastoma: Focusing on the Tc compartment, glioblastoma patients had a shift in the memory compartment with an increase in KLRG1+CD4+ terminal effector Tc (TTE; Tc-I 25) and a reduction in KLRG1+CD4+ transitional memory Tc (TTM; Tc-I 6), KLRG1+CD4+ central memory Tc (TCM; Tc-I 3), KLRG1−CD4+ TCM (Tc-I 9), and CD4+ effector memory Tc (TEM; Tc-I 11) compared to controls (Fig. 5H–L).