Taken together, unsupervised clustering revealed similarities in the Bc compartment between RRMS and glioblastoma patients with an increase in CD19+CD20− DN Bc, CD21− DN memory Bc, and Pc as well as a reduction in activated TZB while CD24+/CD27+ Bregs were only reduced in glioblastoma patients compared to controls. This evidence concerns the gene CD19 and glioblastoma.